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Bacteria engineered to produce IL-22 in intestine induce expression of REG3G to reduce ethanol-induced liver disease in mice

26 Yarema et al 7 reported a lower risk of hepatotoxicity for the IV route when treatment was initiated within 12 hours of ingestion, and the relative risk of hepatotoxicity for patients treated with IV at 10 hours (the cutoff used in our study) was approximately 0.7 compared to oral NAC

After one year, the change in eGFR was significantly higher in the bardoxolone methyl groups as compared with placebo (5.8 1.8 mL/min/1.73 m 2 for 25 mg vs